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Yutaka Seino Selected Research

Obesity

8/2023Oral Semaglutide under Human Protocols and Doses Regulates Food Intake, Body Weight, and Glycemia in Diet-Induced Obese Mice.
1/2023Glucose-dependent insulinotropic polypeptide counteracts diet-induced obesity along with reduced feeding, elevated plasma leptin and activation of leptin-responsive and proopiomelanocortin neurons in the arcuate nucleus.
12/2022D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice.
7/2022d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice.
8/2020A Review of Recent Findings on Meal Sequence: An Attractive Dietary Approach to Prevention and Management of Type 2 Diabetes.
4/2016Efficacy and Safety of the SGLT2 Inhibitor Luseogliflozin in Japanese Patients With Type 2 Diabetes Mellitus Stratified According to Baseline Body Mass Index: Pooled Analysis of Data From 52-Week Phase III Trials.
12/2013Incretin actions beyond the pancreas: lessons from knockout mice.
6/2013Improvement of fasting plasma glucose level after ingesting moderate amount of dietary fiber in Japanese men with mild hyperglycemia and visceral fat obesity.
3/2013Glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1: Incretin actions beyond the pancreas.
1/2012Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice.
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Yutaka Seino Research Topics

Disease

115Type 2 Diabetes Mellitus (MODY)
12/2023 - 05/2002
29Body Weight (Weight, Body)
12/2023 - 04/2003
28Insulin Resistance
02/2019 - 07/2002
22Diabetes Mellitus
05/2019 - 01/2002
21Hypoglycemia (Reactive Hypoglycemia)
07/2018 - 09/2006
18Obesity
08/2023 - 07/2002
16Hyperglycemia
10/2017 - 01/2002
15Glucose Intolerance
01/2021 - 03/2003
8Weight Gain
08/2023 - 04/2014
8Type 1 Diabetes Mellitus (Autoimmune Diabetes)
09/2018 - 08/2002
6Heart Failure
12/2023 - 05/2017
6AIDS-Related Complex (ARC)
01/2023 - 06/2019
5Cardiovascular Diseases (Cardiovascular Disease)
03/2023 - 12/2013
5Myocardial Infarction
03/2023 - 05/2017
4Constipation
01/2022 - 10/2011
4Weight Loss (Weight Reduction)
08/2020 - 10/2010
4Diabetes Complications
12/2013 - 09/2008
3Chronic Renal Insufficiency
12/2023 - 02/2013
3Sarcopenia
10/2023 - 06/2015
3Neoplasms (Cancer)
04/2023 - 06/2019
3Stroke (Strokes)
03/2023 - 01/2020
3Nausea
01/2022 - 11/2015
3Anorexia
10/2021 - 06/2019
3Albuminuria
01/2020 - 03/2014
3Hypertension (High Blood Pressure)
10/2016 - 04/2008
3Ketosis
06/2015 - 08/2008
3Diabetic Nephropathies (Diabetic Nephropathy)
03/2014 - 08/2005
3Bone Fractures (Bone Fracture)
12/2013 - 07/2006
2Urinary Tract Infections (Urinary Tract Infection)
04/2023 - 03/2019
2Pneumonia (Pneumonitis)
04/2023 - 12/2020
2Hyperphagia (Overeating)
07/2022 - 01/2022
2Infections
12/2020 - 10/2010
2Pain (Aches)
12/2020 - 12/2018
2Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
03/2019 - 01/2017

Drug/Important Bio-Agent (IBA)

63Glucose (Dextrose)FDA LinkGeneric
12/2023 - 11/2002
35Insulin (Novolin)FDA Link
12/2021 - 01/2002
21Glucagon-Like Peptide 1 (GLP 1)IBA
12/2022 - 02/2008
19Hypoglycemic Agents (Hypoglycemics)IBA
11/2020 - 12/2004
18LiraglutideFDA Link
08/2022 - 01/2011
17IncretinsIBA
05/2017 - 01/2007
16Glucagon-Like Peptide-1 ReceptorIBA
08/2023 - 02/2008
161,5- anhydro- 1- (5- (4- ethoxybenzyl)- 2- methoxy- 4- methylphenyl)- 1- thioglucitolIBA
01/2020 - 07/2014
14Blood Glucose (Blood Sugar)IBA
08/2023 - 07/2004
12Glycated Hemoglobin (Glycosylated Hemoglobin)IBA
09/2021 - 04/2003
10gastric inhibitory polypeptide receptorIBA
10/2023 - 07/2002
10Glucagon (Glukagon)FDA Link
12/2021 - 11/2008
10Sitagliptin Phosphate (Januvia)FDA Link
01/2021 - 01/2011
9SodiumIBA
12/2023 - 04/2016
9Sodium-Glucose Transporter 2 InhibitorsIBA
10/2023 - 12/2014
9Triglycerides (Triacylglycerol)IBA
01/2018 - 10/2003
9alogliptinIBA
05/2017 - 09/2011
8Dipeptidyl-Peptidase IV InhibitorsIBA
05/2022 - 06/2009
8Glucagon-Like Peptide-1 Receptor AgonistsIBA
01/2022 - 05/2011
7LeptinIBA
01/2023 - 02/2004
7Peptides (Polypeptides)IBA
01/2023 - 05/2011
7lixisenatideIBA
12/2021 - 01/2015
7AdiponectinIBA
02/2013 - 10/2005
6empagliflozinIBA
12/2023 - 03/2019
6Sodium-Glucose Transport ProteinsIBA
10/2023 - 07/2014
6LipidsIBA
01/2023 - 03/2005
5semaglutideIBA
08/2023 - 01/2018
5glimepiride (Amarel)FDA LinkGeneric
01/2021 - 10/2011
5Hormones (Hormone)IBA
01/2017 - 02/2004
5C-PeptideIBA
11/2015 - 08/2008
4Gastric Inhibitory Polypeptide (Glucose Dependent Insulinotropic Peptide)IBA
10/2023 - 07/2002
4GhrelinIBA
07/2022 - 06/2019
4AutoantibodiesIBA
10/2021 - 07/2003
4LinagliptinIBA
01/2021 - 10/2016
4rGLP-1 proteinIBA
09/2017 - 12/2009
4C-Reactive ProteinIBA
02/2013 - 12/2002
3Pro-Opiomelanocortin (Proopiomelanocortin)IBA
01/2023 - 07/2022
3Neuropeptide YIBA
07/2022 - 01/2020
3ninjin'yoeitoIBA
10/2021 - 06/2019
3Cisplatin (Platino)FDA LinkGeneric
10/2021 - 06/2019
3Proteins (Proteins, Gene)FDA Link
08/2020 - 03/2008
3AlbuminsIBA
01/2020 - 02/2013
3Metformin (Glucophage)FDA LinkGeneric
07/2018 - 12/2012
3Glyburide (Glibenclamide)FDA LinkGeneric
04/2016 - 07/2014
3Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
02/2013 - 10/2005
3Streptozocin (Streptozotocin)FDA Link
09/2011 - 02/2002
3corosolic acidIBA
04/2008 - 07/2004
3Adenosine Triphosphate (ATP)IBA
08/2006 - 12/2004
2Fura-2 (Fura 2)IBA
12/2022 - 06/2019
2psicose (D-psicose)IBA
12/2022 - 07/2022
2dulaglutideIBA
01/2022 - 12/2021
2ipragliflozinIBA
01/2021 - 01/2021
2omega-Chloroacetophenone (Mace)IBA
01/2021 - 01/2020
2Dietary FiberFDA Link
08/2020 - 06/2013
2Fatty Acids (Saturated Fatty Acids)IBA
08/2020 - 08/2014
2CarbohydratesIBA
08/2020 - 01/2017
2Appetite Depressants (Anorectics)IBA
01/2020 - 06/2019
22,4-thiazolidinedione (thiazolidinedione)IBA
07/2018 - 01/2018
2saxagliptinFDA Link
12/2017 - 05/2017
2EnzymesIBA
01/2015 - 09/2014

Therapy/Procedure

29Glycemic Control
09/2021 - 10/2005
27Therapeutics
01/2021 - 03/2003
3Kampo Medicine (Kampo)
10/2021 - 06/2019
3Transplantation
10/2011 - 02/2002
3Islets of Langerhans Transplantation
03/2008 - 09/2006
2Aftercare (After-Treatment)
08/2023 - 05/2018